Low dopamine symptoms reddit. Zinc and iron blood levels of at least 100.
Low dopamine symptoms reddit Per Dr. Serotonin binds to this receptor, which inhibits these neurons from releasing dopamine and/or norepinephrine. Low quality posts will be removed. Especially since i haven't experienced any other symptoms of low T like loss of muscle, loss of facial hair, etc. Working up a sweat by running, swimming, dancing, or other I get terrible sleep at least 3 times a week, and I have begun to wonder if dopamine is affecting or may be the cause of my mind racing at night. Parkinson-like symptoms = occurs earlier/develops more acutely due to dopamine receptor blockade = results from low dopamine + high ACh combination e. Most actions for being responsible are high-executive low-reward tasks, so they're very difficult to do Dopamine for example is pretty important for lymphocytes and your immune system interacting with receptors in your spleen, bone marrow, and blood. Administration of 5-HTP alone depletes catecholamines (dopamine, norepinephrine, and epinephrine). Or check it out in the app stores TOPICS. Your symptoms are common among people with low GABA. Common symptoms can include: Chronic anxiety Rumination OCD tendencies Low tolerance for stress Estrogen-dominance related symptoms Possible increased sensitivity to supplemental methyl donors ADDITIONAL INFORMATION. Can methylfolate lower dopamine . Members Online I feel so sleepy all the time with a ringing sound in the back of my head on detox. If a normal dose isn't working, consider other possibilities. Amen low dopamine is related to attention problems. Just now starting b9+b12 and looking for the correct ratio. I have clearly had low dopamine and other neurotransmitter issues all my life but undiagnosed ( I had absolutely the same symptoms as you and it was incredibly debilitating ) really do look into the symptoms of low dopamine and speak to your doctor you will no doubt be shocked at how closely the symptoms are a match, i am much improved now Get the Reddit app Scan this QR code to download the app now. Dopamine is released whenever you do something that feels good, or that gives you some sort of "reward. Not sure how extreme it can be in depression but in schizophrenia, some medications are about diminishing the level of dopamine (we think that the excess of dopamine is what cause hallucinations among other things), if the dopamine level gets too low, patients can develop parkinson-like symptoms (Parkinson disease is linked with a huge dopamine deficiency, that's Dopamine [reward] will have you always going for it. Depression and other mental illnesses, and some physical illnesses, can cause it too. Chronic overmethylation results in excess COMT activity and so, chronic low dopamine. Nothing feels rewarding or enjoyable and I don't feel like moving or doing anything. I've checked a few supplements from reputable companies that cointain both, and the median ratio looks like 1:2 b9 to b12 in mcgs. Since my body metabolize dopamine very quickly, I go through situations which raise dopamine without being very much Things like alcohol addiction, drug addiction, weed addiction, PMO addiction and even sex addiction. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise Blog Careers Press. the ssri do nothing but exacerbate my symptoms. If you slow down the norepinephrine production, you might have more like 50% norepinephrine and 50% dopamine. Anyway, I've tried Wellbutrin in the past and couldn't tolerate it (made me irritable). Low dopamine levels can produce negative reactions throughout the body. Look into Wellbutrin (bupropion). ADMIN MOD Is PSSD low dopamine or impairment of dopamine system? Share Sort by: Best. Obviously have some low serotonin too but the low dopamine symptoms bother me the most. We have recovery meetings several times a week on the StopSpeeding server and the ADHD-medication-focused server also has recovery meetings Get the Reddit app Scan this QR code to download the app now. " So, a true "low-dopamine" routine would mean NOT doing anything that feels good. Nothing makes sense. Eliminating methyls should help even your Can you give me insight. Thanks for Basically, I know I have low dopamine and low seretonin Always had low libido, depression problems, anxiety, all the symptoms of low T, etc. But I'm also confused because the low dopamine has only been here for a few years (I think) but I've had tremors all my life. I’ve been getting iron infusions for 20+ years, it sucks. 12,15 When dopamine depletion is great enough, 5-HTP will no longer function. Fast COMT means I have very little dopamine in resting phase, thats why I might come across as dull. I get so deficient in iron due to absorption issues that I get severe RLS from low dopamine. However, all the symptoms of low dopamine seem to be much more relatable to me. Meds will always be the only real solution, but if that's not an option, caffeine, video games, loud music, dancing, exercise, NSFW activities, whatever brings you joy really, will always be better for your mental health than doom scrolling online. It may be that dopamine and norepinephrine are always in play, but which is the primary culprit varies from person to person. Let's say you have 10 molecules of dopamine made in your brain, per second. It even seems to outperform its closely related cousin, Sulpiride, on a comparable mg-per-mg basis. When dopamine is released in excess, it gets depleted overtime and the brain requires more amount of dopamine, than the excess, to feel normal again. mood swings. Ultra-low dose and normal dose antipsychotics deliver totally opposite effects, the former is an indirect I thought all my problems were due to my brain fog but I have recently realized low dopamine could be a second culprit. (Please note: these symptoms can also occur in PAWS- please visit www. but I think low dopamine feels more like needing to scrounge together enough change to get on the bus or something. Parkinson's disease has been linked to low levels of dopamine and schizophrenia has been linked to high levels of dopamine. But if intense situation arises, I get very energetic. Get your prolactin levels checked if you have seb dermatitis and suspect it's being created from having low dopamine. Which seems very counter-intuitive. transient releases of dopamine in specific parts of the brain (as opposed to a continuous, across the board increase in dopamine as describe in my Not only have the "updated" versions started to integrate other neurotransmitters (notably glutamate) but have suggested that it's actually INCREASES in striatal/subcortical dopamine that lead to the experience of POSITIVE symptoms (hallucinations, delusions, etc. With social media and endless amounts of information from devices, we have limitless opportunities for immediate dopamine hits. It is thought to be majorly responsible for anxious and depressive symptoms. Then you have the D2 receptor, which acts as an autoreceptor (typically in one of its two isoforms) when expressed presynaptically. g. Internet Culture (Viral) Amazing dopamine and stiff muscles and low blood pressure? dopamine deficient genetically but wouldn't the logic follow that s minor deficiency would result in some similar symptoms of a lesser severity? Your baseline dopamine levels are TOO LOW than NECESSARY to function normally. Low dopamine could cause depression, brain fog, poor memory, dysautonomia, reduced color vision, low testosterone, erectile dysfunction, and high blood pressure. How can I know if my Low dopamine levels can manifest in a variety of symptoms, from lack of motivation and fatigue to mood changes and cognitive difficulties. "Low amounts" here means not constantly engaging in things that release some, 1. Testosterone and dopamine levels are interconnected, and when testosterone levels drop significantly, it can lead to various ADHD-like symptoms like binge eating, decreased motivation, and low mood. I. I am ADHD but not currently being treated. Huntington-like symptoms = occurs later = results from high dopamine + low ACh combination e. If it's very bad consider lowering your dose with doctors help, like 18mg concerta and if its not enough for you ask for an instant release booster option, like 5mg will get you thriughthe tougher parts of the day without committing full 8-12 hours to another/higher or even uncomfortable dose. It may be that dopamine is incidental to the norepinephrine problem, and not a cause Psychotic symptoms are definitely a result of many influences, so it's possible low level neuroactive individuals like with depression can still be susceptible to and have worsening symptoms of psychosis due to other less understood contributors. Some people think that it speeds the conversion into serotonin too rapidly and that 5htp dosn;t reach the brain this way . Top. Hi everyone, I suffer from depression dependent on low dopamine levels. Just a speculation. Failure to supply the brain with that amount or withdrawal from the stimulus (eg. I quit cannabis over 9 months ago but I lack in motivation, have no enjoyment in anything, severe anxiety and low mood. My lack of motivation, libido, energy is all time terrible. It truly seems that low dose Amisulpride is indeed a very unique and special treatment for conditions associated with reduced dopamine (ADHD, Depression, Negative symptoms of Psychotic Disorders). Your experience of developing symptoms associated with low dopamine/ADHD after using anabolic and androgenic steroids (AAS) is not uncommon. Of course it’s all connected so if there is dysfunction in one it might affect the other and result in disturbed mood. There is not even one study that relates BH4 and MTHFR with low dopamine production. Lack of Motivation. Low dopamine and high prolactin can be symptoms of micro or macro-adenomas - benign tumors on the pituitary gland; low dopamine / high prolactin can also be medication induced, or caused by damage to the ends of specific neurons From what I've understood, usually an undermethylator has low dopamine and serotonin, thus he could boost methylation and the production of neurotransmitters by supplementing B vitamins and methyl donors, such as SAM-e, creatine and TMG. Parkinson's is what happens if you have "more dopamine". Low serotonin could cause depression and cognitive problems, as well as insomnia. So other than all my life meeting symptoms of low dopamine (not the extreme as in parkinsons deficient dopamine), I was able to receive an explanation that I have a genetic polymorphism that occurs in 4-5% frequency in my ethnic population (Caucasian: European and/or Mediterranean). The article just lists and describes how a dopamine deficiency can manifest certain symptoms and what may’ve caused it, but I’m wondering if anyone else feels like this could be applicable to them. I know there is great debate about taking 5htp with b6. Once dopamine secreted it needs to replaced, which is time consuming (moving empty vesicles back to the soma if the neurons, glia cells need to clean synapse and recycle the dopamine). Welcome to Dopamine Detoxing. To follow that metaphor, sufficient dopamine feels like you made it on the bus on time and you’re on your way to the place you They both exploit the same limited dopamine stores in the synapse (and hence are anti correlated). He adds that the characteristic tremors, stiffness Symptoms of Dopamine Deficiency. I use my phone all the time for that on Facebook reels and even Pinterest. SurvivingAntidepressants. Meanwhile Chatgpt/reddit says: Medicine - Dopamine agonists (e. I wonder how much our personalities actually change when we have the same amount of energy like if we were on stimulants like those prescribed medications. I have dementia like symptoms and get confused very easily trying to pay bills, Cook, and clean. [37][38] In addition to its therapeutic effects, activation of the MOR is likely to also be responsible for the So if you want to deal with that and avoid this outcome, then you need to actively avoid most instant gratitification and get used to low amounts of dopamine. It may be that there are multiple conditions at play here, and the constellation of symptoms is what we've readily identified. I think it’s getting really bad. Stiff neck, sore muscles and all that are low dopamine symptoms. hard time getting going in the morning. Typical ADHD / ADD symptoms. Official StopSpeeding Server (stop your speeding of any kind), or if you just struggle with ADHD medication, you might feel more at home at our ADHD medication focused server. org if you are new/if you have PAWS). This is why caffeine and other dopamine releasing agents can cause a comedown if used in excess. forgetfulness. When test aromatizes into estradiol, it causes the release of prolactin, when prolactin is release, it causes a release of dopamine in specific parts of the brain since dopamine is your bodies mechanism of combating prolactin levels. The polygenic score for But we DO know what low dopamine does in people with Parkinson's, so we do have a relatively predictable pattern of signs and symptoms. Learn more about the symptoms. You can realise on a scale of low normal and excessive amounts, we fall to the “low category”. Almost everyone on here talks about low T being the cause of this and going on TRT but I feel like it has a lot more to do with dopamine. Tyrosine hydroxylase requires BH4 to produce L-Dopa. 5; those with lower signaling were assigned a score of 0 . What are ‘low' Dopamine genotypes? Enter Dopamine Polygenic Scores. If the relevant neurons aren’t firing properly you might have symptoms of low serotonin/dopamine. all of the depressive symptoms come back. I miss my usual hobbies. Tardive dyskinesia Other symptoms of low dopamine levels include: Hand tremors or other tremors at rest, loss of balance or coordination, increased muscle/limb stiffness, muscle cramps (symptoms of Parkinson’s disease). I absolutely felt my dopamine plummet in the second week of covid infection. If you study ADD or ADHD both having excessively low levels of dopamine. A LOW Dopamine + Low Norepinephrine State is more Severe and presents like this Severe Depression and loss of Interest (Anhedonia). In this clip we review reasons why abnormal dopamine levels can cause addiction in untreated individuals, and why psychostimulant treatment for ADHD and addiction disorders could be useful in offsetting the future addictive liability present in individuals with naturally low levels of dopamine in chief brain regions governing reward and attention in the article "Individual differences in the This is a support group to help with impulsive behaviour towards Eating, Gaming, Gambling, Thrill, and Tech. It also important for your kidney function and pancreas. Not even watching tv. Every symptom. The symptoms of a dopamine deficiency vary greatly based on what’s causing it. 15 If other centrally acting monoamine-related disease processes involving catecholamines are present, administration of 5-HTP alone may deplete dopamine, norepinephrine and Yes. The causes of dopamine deficiency are diverse, ranging from genetic factors and "Parkinson's disease, where neurons that make dopamine die off prematurely, is the classic example of this," says Dr. If your brain converts 7 of those molecules of dopamine into norepinephrine, at any one time you'll have 70% norepinephrine and 30% dopamine. I am currently on day 69 of nofap and I've been suffering from symptoms of low dopamine. Therapy and counseling can be valuable components of managing low dopamine symptoms, particularly when they’re associated with mood disorders or anxiety. Avoid caffeine if these are your problems because it antagonizes GABA and enhances noradrenaline activity. See the COMT section of this post for more information. The issue stems from having generally lower stimulus to the brain, and therefore seeking activities and substances that will provide it easily. Any good supplements etc to try? I've been trying l tyrosine and l theanine aswell as a methylated multivitamin but symptoms just as bad. I’ve come to this huge realization today (and am now in bed still feeling shocked) that almost every personal struggle I have now is a result of instant gratification and low dopamine. Chronic low dopamine contributes to the ADHD pathology. According to Adrienne et al. It’s been a year later and I’m severely struggling. Chronic very low glycine results in chronic little to no glycine buffer function. That might sound strange, but for me personally, one of my coping method for my nervousness is to occupy myself in an erratic way, like going to the store without needing it, washing clothes, or something. It's used to help quit smoking, against narcolepsy, around seventh in line for what doctors prescribe against depression, and may be used as an "if all else fails" ADHD medication, but it targets the dopamine reuptake which we all know is a great part of what messes us up. This is a support group to help with impulsive behaviour towards Eating, Gaming, Gambling, Thrill, and Tech. I started taking methylpro 10mg about a week ago and i’m starting to get some general low dopamine type symptoms. Zinc and iron blood levels of at least 100. I can't think of much else to do aside from electronics, I think it certainly would've been easier if I had friends to distract The receptor 5-HT2c is one that mediates the release of dopamine and adrenaline, generally as it becomes more active dopamine is lowered and adrenaline is released in higher amounts. I do also have a autoimmune disease that attacks the myelin sheath so I am in a lot of pain, so of course that slows me down as well. Ergo Parkinson tremor and other essential parkisonism symptoms. Low doses of clonazepam are also helpful as neuro muscle relaxers and work nicely with the C/L to mostly control the dystonia and other symptoms. If your sleep is out of whack, fix your circadian rhythm and melatonin levels. Same_Association9018. I stopped taking Wellbutrin cold turkey and went through terrible withdrawals. Without dopamine it would send your immune system into overdrive and is suspected to be one of the causes of autoimmune disorders. View community ranking In the Top 10% of largest communities on Reddit. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. I have lived with this problem for years and if I don't find a solution I will evaluate euthanasia. Looking at your post history, your problems aren't going to be solved by a legal or grey market substance. I was on Lexapro for 1. ) while DECREASES in frontal/cortical dopamine result in NEGATIVE symptoms (anhedonia, The substantia negra region of the brain has the densest population of dopamine synapses, and deterioration of this area is associated with Parkinson's disease. Posted by u/HeyitsmeurAccount - 16 votes and 8 comments TYPICAL SYMPTOMS. Low nitric oxide could cause erectile dysfunction and high blood pressure/heart disease. Tbh, I wonder if my brain will ever feel better without some sort of thing giving me more dopamine, but I honestly don't fully understand the relationship between prolactin and dopamine. There also might be some hereditary aspect to this, because my father, and his father both had tremors too. It's a NDRI, a noreponephrine-dopamine-reuptske-inhibitor. From novel/alternative substances, to established medications. Movement Disorders. Open comment sort options. Best. 1M subscribers in the NoFap community. Lack of Emotions. I have already tried the bupripion at 450mg but it hasn't worked except for a very short period. The same nutrition will produce a different result in me as in someone else with a slow COMT and a high number of receptors. (2018), genotypes that are associated with relatively higher dopamine signaling were assigned a score of 1; those with intermediate signaling were assigned a score of 0. I'm diagnosed with adhd, take adderall and dexedrine. Wellbutrin helps dopamine. Taken with other adhd symptoms is the key. D of 80. Introversion and shyness (personality characteristics) are not social anxiety (mental distress). Problems with short-term memory, managing daily tasks and solving simple thinking problems (symptoms of cognitive changes). Low dopamine levels are linked with certain health conditions, such as Parkinson’s disease or Dopamine deficiency refers to low levels of dopamine in the brain which can adversely affect our emotional responses and movements. Low methyldonors means higher Dopamine since the COMT enzymes uses methyldonor to degrade them, high dopamine means easier ability to focus and higher basal stress levels. They may include: Sadness or hopelessness; Muscle spasms, tremors, or cramps; Slower movements and Several psychological and physical symptoms can appear when there is a dopamine deficiency. Can methylfolate do this? Also what is methylfolates effect on histamine? comments •Stomach acid could be low, lending to SIBO and poor breakdown of aminos needed for neurotransmitter production •Poor absorption of nutrients from the SIBO needed to make dopamine •High oxidative stress (inflammation) impairing BH4 and dopamine creation •Strep (if present in high amounts in the SI) breaks amino acids into the wrong peptides •There could be Sorry for my bad English. Hi, thanks Depressive symptoms can have many forms and I think that an antidepressant could possibly reduce your anxiety which could result in less motivation. You don't need to supplement melatonin - just block all blue light in the evening so your pineal gland can produce it, and get some bright light in the early morning. It's been emotionally numb since then. I think I'm seriously low in dopamine. 3 studies below both confirmed low to ultra-low dose haloperidol can enhance dopamine supersensitivity and is safe, well tolerated. This is a support and discussion community for people who have these symptoms. In general anti-psychotic medications affect dopamine secretion in certain synapses, or dopamine re-uptake, or dopamine receptors, but this doesn't really tell us much. I've worked on it by (1) taking as little melatonin as possible, (2) reducing sugar and junk food, (3) taking Vitamin D and magnesium daily, (4) limiting overindulgance in shopping and masturbation so I can still feel pleasure from things I like, and (5) increasing these foods: legumes, nut butters, seeds, apples, avocados, bananas, watermelon, beets, and green leafy vegetables. I recently added Dysport injections about 2 years ago as with Dopa Responsive Dystonia you may still get areas of focal dystonia along with generalized dystonia. Restless legs syndrome. 5-HT_2c is a dopamine/noradrenaline inhibitor for example, so if you block this serotonin receptor you disinhibit dopamine and noradrenaline function, if you increase serotonin or use an agonist it decreases activity of these neurotransmitters. I have been feeling very tired. Internet Culture (Viral) Amazing insomnia, and cold/flu-like symptoms) do manifest following prolonged usage of dose usage far beyond the medical range. Search reddit for info on memantine, it’s known to upregulate dopamine receptors via nmda Physical symptoms may include: blushing, excess sweating, trembling, palpitations, and nausea, stammering, along, rapid speech, panic attacks. Note that I asked if they are useful for people who have ‘low' Dopamine genotypes () or Dopamine receptor down-regulation, not for normal people. 5 years and that was helpful for a while but I eventually felt numb so so weaned off. Anyhow working of the neurotransmiters are all connected so you may take into consideration all of it in your state. I just know I factually have TOO much prolactin and symptoms that indicate low dopamine. " No one knows why this occurs, and it probably has more than one cause. Narcolepsy-like Symptoms; idiopathic hypersomnia; excessive tiredness. Low dopamine? And I sure run low on dopamine. For a long time now I’ve suspected I might just be suffering from a pronounced deficiency of sorts How to Treat Low Dopamine Symptoms . Hence the amount if available dopamine is a limited resource. Essentially my story isI took ritalin from 8 years old to 12 and then SSRIs from like 15-28. Beta alanine increases GABA by being a GABA reuptake inhibitor, slows the conversion of dopamine to noradrenaline at DBH, and because of those two things also raises dopamine. Not even stimulants or any ADHD medication for that matter has ever helped me If you need someone to talk to, join us on Discord. . Thus, the binding of dopamine to these particular receptors inhibits the pre-synaptic release of dopamine. I know low dopamine can make it hard to focus, enjoy previously enjoyable experiences, and as well make you experience depressive symptoms. Your dopamine levels are likely below baseline and always have been. Masturbation in moderation is When you're hyperfixating or doing a low-executive high-reward task you have plenty of dopamine. This idea is ass-pulled. Deficiency in BH4 is fatal if not discovered early as it leads to build up of phenylalanine. Lack of Ambition, Zest, Awareness. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. Parkinson's disease is related to deterioration of the "substantia nigra. The only fix for that is more dopamine. , cabergoline, bromocriptine, P5P/Vitamin-B6) Herbal - Vitex agnus-castus (Chasteberry) Lifestyle - Stress Reduction Dietary - Avoiding Certain Foods like Soy high in phytoestrogens. Get the Reddit app Scan this QR code to download the app now. I actually learned how to control dopamine for my benefit. However, if an undermethylator has also slow COMT, it usually means that dopamine (and adrenaline) is high. Also the 4 subscribers in the FitnessForFoodies community. This makes me wonder if I'm just a chronically low dopamine person and some days I dip so low it starts mimicking Parkinson's disease. insomnia. Too little dopamine can contribute to cognition issues such as attention deficit hyperactivity disorder (ADHD), an inability to Get the Reddit app Scan this QR code to download the app now. lack of motivation. Cognitive-behavioral therapy (CBT) can help Dopamine releasing compounds can deplete dopamine levels in the synaptic cleft over time through various mechanisms, including downregulation and desensitisation of the DA receptors. Dopamine is more to do with processing and carrying out an activity. inability to experience pleasure. The worst is a severe worsening of restless leg syndrome. That way when it kicks in my mind is associative the feel good/dopamine reward with exercise. Chronic little to no glycine buffer function results in chronic overmethylation. A porn addiction and compulsive sexual behavior recovery peer support forum. What the trend is actually encouraging, though, is a new dopamine routine. I (we) should have an equal need of both, according to genetics. Do you think I am low on dopamine? My nervous system can't take stress. Ondo. TRT I had low sex drive, fatigue, brain fog, interest, drive etc since years. Is it all a neurotransmitter deficiency issue, or is something else the problem? Can low dopamine commonly cause low libido? Lab #s from early June: So I’m a guy with chronically low dopamine symptoms. fatigue. Some things that you can do to fix low dopamine include getting regular exercise, eating foods that support dopamine production, consuming probiotics, and listening to music Exercise . Discussion and anecdotes are welcome! This sub is not for venting or for facebook style posts. I will consume my adderall only 15mins before walking into the gym. This can cause dopamine deficiency syndrome, which is a hereditary movement Dopamine deficiency has links to several health conditions, including Parkinson's disease and depression. It might not be a complete failure but low dopamine is common. Still getting post acute withdrawal symptoms. Pandemics bring post viral syndromes with dysfunctional dopamine neurons. Have you used stimulants recently? That would Dopamine deficiency means you have a low level of the neurotransmitter dopamine. Reddit iOS Reddit Android Reddit Premium About Reddit Advertise and she (perfectly) diagnosed me with low dopamine. acute dystonia/akathisia. Hello. "More dopamine" is pure nonsense that won't give you answers that work. Over and under methylation is another ass-pulled idea from the 1960. Also TRD for 30 years so that tracks. RESOLUTION Copper and zinc blood levels should be about equal to minimize anxiety, irritability, etc. I have anxiety. I feel like a rat in one of those dopamine experiments. I am trying to pinpoint the root cause of these issues. Looking at your phone (or any electronics, really View community ranking In the Top 10% of largest communities on Reddit. Or check it out in the app stores Low level of dopamine may cause panic attacks because you don't feel much feedback from your reward system so you wan't satisfy it as quick as possible. For example I have a fast COMT (enzyme pathway that breaks down dopamine) and genetically lower amount of dopamine receptors. Internet Culture (Viral) Amazing Advice for possible chronic low dopamine? Hello, ive read through the beginners guide but there is quite a lot of info out there. Selfhacked makes more sense. Low dopamine means low thresholds and so low inhibition of movement which means more movement impulses are received and relayed which is disordered and not well opposed or mediated by the cerebellar. Start with a Dopamine Detox, then maintain a Dopamine Fast. Where gastronomy and gym life intersect Many people say that loss-of-function COMT mutations, favoring the accumulation of synaptic catecholamines (dopamine & norepinephrine), increases vulnerability to anxiety/irritability with certain drugs and supplements, especially methyl donors like Methylfolate and Methylcobalamin - indeed, S-Adenosyl-Methionine (SAM), the body's universal methyl donor, may increase brain Less is more with this stuff. ibvunv mpioabn hynh ozmnuh rrekgbln oqcf gywoy pjlg jjqhj dmozfu foh uvgxt hxlvra qrz qjoie